Does IVIG Weaken the Immune System? Dispelling Misconceptions and Understanding Its Role
Does IVIG Weaken the Immune System? Dispelling Misconceptions and Understanding Its Role
The ImmunoGlobulin Intravenous (Human) (IVIG) is a critical treatment for individuals with primary immunodeficiencies, such as Crystal. After 30 years of receiving IVIG infusions, my experience highlights the complexities and often misunderstood effects of this therapy. This article aims to clarify the misconceptions surrounding IVIG, emphasizing its role in supporting and strengthening the immune system.
Crystal’s Story: 30 Years of Living with IVIG
Crystal was born genetically immune deficient and had to receive IVIG infusions every 28 days. She was diagnosed with Stage III recurrent head and neck cancer about four years ago, making her journey even more challenging. Despite the rigors of her condition and treatments, she emphasizes the importance of IVIG in her life.
IVIG is a blood product that combines immunoglobulins from multiple human blood donors. It serves as a crucial supplement for individuals whose immune systems are deficient or compromised. In Crystal's case, IVIG is the only part of her immune system that can be infused, providing some efficacy against infections.
Understanding IVIG and Its Role in the Immune System
Immunoglobulins are proteins produced naturally by the body's immune system to fight off infections. IVIG acts as a concentrated form of these antibodies. When Crystal received her first IVIG infusion, she could only feel two minor side effects: fatigue and a slight fever on infusion day. These side effects are minimal compared to the life-altering consequences of her cancer treatments.
IVIG: Beyond a Simple Infusion
Contrary to the misconception that IVIG might weaken the immune system, it actually enhances it. In autoimmune disorders, immunotherapy medications suppress the immune system to reduce adverse effects. However, for cancer patients, immunotherapy aims to strengthen the immune response to detect and attack tumor cells. For example, immune checkpoint inhibitors remove restrictions and roadblocks in the immune pathway.
Chemo and radiation treatments are often prescribed alongside immunotherapy and can temporarily lower immune function. So, IVIG serves as a vital supplement during these times, providing the necessary support to keep the immune system active and effective.
Side Effects and Efficacy of IVIG
Cancer patients like Crystal frequently experience side effects and the need for life-altering treatments. Her diagnosis with Stage III recurrent head and neck cancer has been a challenge, but the IVIG infusions have played a crucial role in maintaining her immune system's functionality.
Crystal currently weighs 73 pounds and is unable to swallow food, facing liquids limited to a feeding pump formula that provides all her nutrition. She has had five episodes of aspiration pneumonia in the past four years and has experienced sepsis multiple times.
IVIG: A Lifeline During Critical Times
During these critical times, IVIG acts as a lifeline, providing critical immunoglobulins to support the body's defense mechanisms. The side effects from 30 years of receiving IVIG have been minimal, mainly limited to fatigue and a slight fever on infusion days. This speaks to the safety and efficacy of IVIG in supporting those with compromised immune systems.
Conclusion
In conclusion, IVIG does not weaken but rather strengthens the immune system, especially in individuals like Crystal, who deals with complex medical conditions. It serves as a crucial supplement to an already compromised system, supporting the body's natural immune response and providing essential protection against infections and diseases.
Crystal's experience underscores the importance of accurate information about IVIG and its role in the immune system. Understanding these facts can help both patients and healthcare providers make informed decisions about treatment options.