Sativex and the High: Understanding the Science

Many people wonder if it is possible to experience a high from Sativex, a spray containing a 1:1 THC:CBD ratio. The answer is affirmative, albeit with considerations of individual factors and dosages. Sativex is a full plant extract, not a synthetic version, and has undergone decarboxylation, a process that converts raw cannabinoid acids, such as THCA, into the more potent THC form.

The Active Ingredients and Their Effects

The primary active ingredients in Sativex are THC (tetrahydrocannabinol) and CBD (cannabidiol). THC is responsible for the psychoactive effects, such as the high, that users experience. CBD, on the other hand, often helps to moderate these effects, especially by reducing anxiety. However, even with the presence of CBD, the psychoactive effects of THC are still present in Sativex.

It's important to note that the concentrations of THC and CBD in Sativex can still produce a high, especially when used in sufficient quantities. The psychoactive properties of THC are a result of its conversion from THCA, which is non-psychoactive in its raw form. Sativex is specifically designed to deliver THC in a psychoactive state, catering to those seeking relief from severe symptoms such as those associated with multiple sclerosis (MS).

Why Does It Get You High?

The high induced by Sativex is not just theoretical. Individuals can empirically test this by using the product themselves. However, the effects can vary widely among different individuals. Factors such as hepatic function, metabolism, and individual tolerance can all influence the intensity of the experience.

For example, someone with impaired hepatic function may experience stronger effects due to slower metabolism. It's also worth noting that the small dose recommendation (around 10 squirts to achieve the same THC content as a 25 mg edible) makes the high less pronounced. Additionally, since Sativex is absorbed directly into the bloodstream, the THC does not undergo the conversion to 11-Hydroxy-THC that typically occurs in the liver, which can enhance the high.

Conclusion

While the presence of CBD can moderate the high, it does not entirely eliminate it. The high experienced from Sativex is a result of the significant THC content in the spray, akin to more traditional forms of cannabis such as flower or edibles. The drug designers may have chosen not to fully convert all THCA to THC to align with cultural perceptions of cannabis use.

Giving the high profile of MS patients, the benefit of the high, even if slight, should be considered against the severe symptoms they are experiencing. Therefore, Sativex can indeed get you high, but the intensity and experience can vary significantly based on individual factors and usage patterns.

Keywords: Sativex, THC, CBD, Multiple Sclerosis, Psychoactive Effects.